Zhenyu Li

From 2019-2024:

• S Wang, Y Zhou, ZY Li, “A microfluidic cover converts a standard 96-well plate into a mass-transport-controlled immunoassay system”, Biomicrofluidics 18 (1), 2024.
• RS Downen, Q Dong, JL Chen, ZY Li, “Design and fabrication of a low-cost microfluidic cartridge with integrated pressure-driven check valve for molecular diagnostics platforms”, Journal of Micromechanics and Microengineering 33 (11), 115003, 2023.
• D McLeod, L Wei, ZY Li, “A standard 96-well based high throughput microfluidic perfusion biofilm reactor for in situ optical analysis”, Biomedical Microdevices 25 (3), 26, 2023.
• W Li, D McLeod, JT Ketzenberger, G Kowalik, R Russo, ZY Li, MW Kay, E Entcheva, “High-throughput optical sensing of peri-cellular oxygen in cardiac cells: system characterization, calibration, and testing”, Frontiers in Bioengineering and Biotechnology 11, 1214493, 2023.
• S. Wang, B.C. Li, D McLeod, Z.Y. Li, “A handheld plug-and-play microfluidic liquid handling automation platform for immunoassays”, HardwareX 14, e00420, 2023.
• R.S. Downen, Q. Dong, E. Chorvinsky, B.C. Li, . Tran, J.H. Jackson, D.K. Pillai, M. Zaghloul, Z.Y. Li, “Personal NO2 sensor demonstrates feasibility of in-home exposure measurements for pediatric asthma research and managemen”, Journal of Exposure Science & Environmental Epidemiology 32 (2), 312-319, 2022.
• Q. Dong, R.S. Downen, B.C. Li, N. Tran, Z.Y. Li, “A Cloud-Connected Multi-Lead Electrocardiogram (ECG) Sensor Ring”, IEEE Sensors Journal, 2021.
• B.C. Li, RS Downen, Q Dong, N Tran, M LeSaux, AC Meltzer, Z.Y. Li, “A Discreet Wearable IoT Sensor for Continuous Transdermal Alcohol Monitoring—Challenges and Opportunities”, IEEE Sensors Journal 21 (4), 5322-5330, 2020.
• L. Wei, W. Li, E. Entcheva, Z.Y. Li, “Microfluidics-enabled 96-well perfusion system for high-throughput tissue engineering and long-term all-optical electrophysiology”, Lab chip 20, 4031-4042, 2020.
• Q Dong, B Li, RS Downen, N Tran, E Chorvinsky, DK Pillai, ME Zaghloul, Z.Y. Li, “A Cloud-Connected NO2 and Ozone Sensor System for Personalized Pediatric Asthma Research and Management”, IEEE Sensors Journal 20 (24), 15143-15153, 2020.
• B.C. Li, Q Dong, RS Downen, N Tran, JH Jackson, D Pillai, M Zaghloul, Z.Y. Li “A wearable IoT aldehyde sensor for pediatric asthma research and management”, Sensors and Actuators B: Chemical 287, 584-594, 2019.
• S Guo, D Yang, S Zhang, Q Dong, B Li, N Tran, Z.Y. Li, Y Xiong, M. Zaghloul, “Development of a Cloud‐Based Epidermal MoSe2 Device for Hazardous Gas Sensing”, Advanced Functional Materials 29 (18), 1900138, 2019.

From 2013-2018:

• Y. Qiao, Q. Dong, B.C. Li, S. Obaid, C. Miccile, R.T. Yin, T. Talapatra, Z. Lin, S. Li, Z.Y. Li, I.R Efimov, “Multiparametric slice culture platform for the investigation of human cardiac tissue physiology”, Progress in biophysics and molecular biology, 1,       2018.
• Guan, P Hamilton, Y Wang, M Gorbet, Z.Y. Li, KS Phillips, “Medical devices on chips”, Nature Biomedical Engineering 1 (3), 0045, 2017.
• Guan, Z.Y. Li and K. S. Phillips, “The effects of non-ionic polymeric surfactants on the cleaning of biofouled hydrogel materials”, Biofouling, Aug. 2015.
•  J. Frey, A. Guan, Z.Y. Li, S. Turtil, K.S. Phillips, “Hemoglobin assay for validation and quality control of medical device reprocessing”, Analytical and Bioanalytical Chemistry, July 2015.
• Guan, A. Shenoy, R. Smith and Z.Y. Li, "Streamline based design guideline for deterministic microfluidic hydrodynamic single cell traps", Biomicrofluidics vol. 9, 024103, Mar. 2015.
• B.C. Li, L. Li, A. Guan, Q. Dong, K.C. Ruan, R.G. Hu, and Z.Y. Li, "A Smartphone Controlled Handheld Microfluidic Liquid Handling System", Lab Chip, 14 (20), 4085 - 4092, 2014.
• Guan, Z.Y. Li, K.S. Phillips, "The Effect of Fluorescent Labels on Protein Sorption in Polymer Hydrogels", Journal of Fluorescence, DOI: 10.1007/s10895-014-1450-8, Sept. 2014.
•  J. Silver, Z.Y. Li, K. Neuman, "Tethered-Bead Immune Sandwich Assay", Biosensors and Bioelectronics, July 2014.
• N. Kotagiri, Z.Y. Li, X. Xu, S. Mondal, A. Nehorai, and S. Achilefu, "Antibody Quantum Dot Conjugates Developed via Copper-free Click Chemistry for Rapid Analysis of Biological Samples Using a Microfluidic Microsphere Array System," Bioconjugate Chemistry, Article ASAP, 2014.
• X. Xu, Z.Y. Li, P. Sarder, N. Kotagiri, and A. Nehorai, "Simultaneous detection of multiple targets using optimized microfluidic microsphere-trap arrays," J. Micro/Nanolith. MEMS MOEMS. 13(1), 013017, Mar 26, 2014.
• X. Xu, Z.Y. Li, and A. Nehorai, "Finite element simulations of hydrodynamic trapping in microfluidic particle-trap array systems," Biomicrofluidics, vol. 7, 014305, Sep. 2013.
• B Zhang, Z.Y. Li, CE Korman, ME Zaghloul, "Rectangular CMOS differential MAGFET biosensor for magnetic particle detection", IEEE Transactions on Magnetics, 49 (7), 4052-4055, 2013.
• Zhang, Q. Dong*, C.E. Korman, Z.Y. Li and M.E. Zaghloul, “Flexible packaging of solid-state integrated circuit chips with elastomeric microfluidics”, Sci Rep. 3: 1098, 2013.
• X.X. Xu+, P. Sarder+, Z.Y. Li+, and A. Nehorai, "Optimization of microfluidic microsphere-trap arrays", Biomicrofluidics 7, 014112 (2013). +Equal Contributions

• Program Committee Member of SPIE Ultrafast Optical Imaging and Spectroscopy, 2013 - now
• Program Committee Member of the 3rd European Optical Society Conference on Optofluidics, 2015
• FDA/CDRH Technical Review Committee (TRC) Member, 2012
• Session Chair of SPIE Ultrafast Optical Imaging and Spectroscopy Conferences 2014, 2015
• Session Co-Chair of IEEE Sensors Conference, Taipei, 2012
• Reviewer of grants submitted to NSF and NIH.
• Reviewer of conference papers for the Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

Reviewer of manuscripts submitted to following journals

• Scientific Reports
• Lab on a Chip
• Annals of Biomedical Engineering
• Biomicrofluidics
• Applied Physics Letters
• Optics Letters
• Optics Express
• IEEE Journal of Sel. Top. Quant. Electron.
• IEEE Photonics Technology Letters
• Applied Optics
• Optics Communications
• Journal of Applied Physics
• Sensors and Actuators A
• AIP Advances

Memberships

• Member of BMES
• Member of IEEE, IEEE LEOS, IEEE EMBS
• Member of OSA
• Member of SPIE

Extramural Grant Support

• 2015 - 2019 NIH-NIBIB 1U01EB021986-01, "Ambulatory Sensor Arrays for Real-Life Monitoring of Pediatric Patients with Asthma", Role: PI
• 2018 - 2019 NSF 1743662, "FDA Scholar-in-residence: On-chip optical biosensing methods for quantitative measurement of antibiotic resistance", Role: PI
• 2018 - 2019 NSF 1837892, "I-Corps: A Cloud-based Wearable ECG Sensor on a Finger Ring", Role: PI
• 2018 - 2019 Johnson & Johnson Vision Care, "Microfluidic Devices for Evaluating Tear Deposition on Contact Lenses", Role: PI
• 2018 - 2022 NSF 1830941, "EFRI CEE: Human cardiac optoepigenetics with HDAC inhibitors – linking chromatin dynamics to electromechanical phenotype", Role: Co-PI

• Z.Y. Li, D. Psaltis, A. Scherer, Z.Y. Zhang, "Mechanically Tunable Elastomeric Optofluidic Distributed Feedback Dye Laser", US Patent 7,817,698
• Z.Y. Li. M. Zaghloul, B.W. Zhang, C. Korman,  Flexible IC/Microfluidic Integration and Packaging  US Patent 9,116,145
• Z.Y. Li, A. Scherer, "Handheld Low Pressure Mechanical Cell Lysis Device with Single Cell Resolution", US Patent Application 20120091235
• B.C. Li, Z.Y. Li, "Handheld Microfluidic Liquid Handling System", PCT Patent Application
• J. Silver, Z.Y. Li, K. Neuman, "Tethered-Bead Immune Sandwich Assay", PCT Patent Application (NIH and GW joint application)
• Z.Y.Li, Q. Dong, M.E. Zaghloul, "Wearable ECG Sensor on a Finger Ring", PCT Patent Application