Junghun Cho

Professor in black suit and tie

Junghun Cho

Professor


Contact:

Email: Junghun Cho

Dr. Cho's research focuses on developing novel magnetic resonance imaging (MRI) techniques for quantifying clinically relevant tissue properties, including cerebral oxygenation, and applying these methods to advance the understanding and treatment of neurological disorders such as dementia, stroke, Parkinson’s disease, multiple sclerosis, cerebral small vessel disease, and brain cancer. His work spans biophysics modeling, advanced image reconstruction, quantitative data analysis, validation, and translational studies that bridge engineering innovation with clinical applications.


  • PhD: Cornell University, Biomedical Engineering 2014-2019
    Thesis: Biophysics model improvement in MRI: cerebral metabolic rate of oxygen
    Advisor: Yi Wang, PhD
  • MS: University of Wisconsin Madison, Physics 2009-2010
  • BS: University of Michigan Ann Arbor, Physics 2006-2008

Cerebral metabolic rate of oxygen (CMRO2) mapping by combining quantitative susceptibility mapping (QSM) and quantitative blood oxygenation level‐dependent …

J Cho, Y Kee, P Spincemaille, TD Nguyen, J Zhang, A Gupta, S Zhang, ...
Magnetic resonance in medicine 80 (4), 1595-1604
 

Quantitative susceptibility mapping (QSM) algorithms: mathematical rationale and computational implementations

Y Kee, Z Liu, L Zhou, A Dimov, J Cho, L De Rochefort, JK Seo, Y Wang
IEEE Transactions on Biomedical Engineering 64 (11), 2531-2545
 

Susceptibility underestimation in a high‐susceptibility phantom: dependence on imaging resolution, magnitude contrast, and other parameters

D Zhou, J Cho, J Zhang, P Spincemaille, Y Wang
Magnetic resonance in medicine 78 (3), 1080-1086
 

Dual MRI T1 and T2 (⁎) contrast with size-controlled iron oxide nanoparticles

H Jung, B Park, C Lee, J Cho, J Suh, JY Park, YR Kim, J Kim, G Cho, ...
Nanomedicine: Nanotechnology, Biology and Medicine 10 (8), 1679-1689
 

Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with 15O PET in healthy adults

J Cho, J Lee, H An, MS Goyal, Y Su, Y Wang
Journal of Cerebral Blood Flow & Metabolism 41 (7), 1658-1668
 

Cluster analysis of time evolution (CAT) for quantitative susceptibility mapping (QSM) and quantitative blood oxygen level‐dependent magnitude (qBOLD)‐based oxygen extraction …

J Cho, S Zhang, Y Kee, P Spincemaille, TD Nguyen, S Hubertus, A Gupta, ...
Magnetic resonance in medicine 83 (3), 844-857
 

Quantitative susceptibility mapping‐based cerebral metabolic rate of oxygen mapping with minimum local variance

J Zhang, J Cho, D Zhou, TD Nguyen, P Spincemaille, A Gupta, Y Wang
Magnetic resonance in medicine 79 (1), 172-179
 

Deep neural network for water/fat separation: supervised training, unsupervised training, and no training

R Jafari, P Spincemaille, J Zhang, TD Nguyen, X Luo, J Cho, D Margolis, ...
Magnetic resonance in medicine 85 (4), 2263-2277
 

Initial experience of challenge-free MRI-based oxygen extraction fraction mapping of ischemic stroke at various stages: comparison with perfusion and diffusion mapping

S Zhang, J Cho, TD Nguyen, P Spincemaille, A Gupta, W Zhu, Y Wang
Frontiers in neuroscience 14, 535441
 

Cerebral oxygen metabolism from MRI susceptibility

E Biondetti, J Cho, H Lee
Neuroimage 276, 120189
 

Using an artificial neural network for fast mapping of the oxygen extraction fraction with combined QSM and quantitative BOLD

S Hubertus, S Thomas, J Cho, S Zhang, Y Wang, LR Schad
Magnetic resonance in medicine 82 (6), 2199-2211
 

Temporal clustering, tissue composition, and total variation for mapping oxygen extraction fraction using QSM and quantitative BOLD

J Cho, P Spincemaille, TD Nguyen, A Gupta, Y Wang
Magnetic resonance in medicine 86 (5), 2635-2646
 

Brain oxygen extraction fraction mapping in patients with multiple sclerosis

J Cho, TD Nguyen, W Huang, EM Sweeney, X Luo, I Kovanlikaya, ...
Journal of Cerebral Blood Flow & Metabolism 42 (2), 338-348
 

Cerebral OEF quantification: a comparison study between quantitative susceptibility mapping and dual‐gas calibrated BOLD imaging

Y Ma, H Sun, J Cho, EL Mazerolle, Y Wang, GB Pike
Magnetic resonance in medicine 83 (1), 68-82
 

Multiecho complex total field inversion method (mcTFI) for improved signal modeling in quantitative susceptibility mapping

Y Wen, P Spincemaille, T Nguyen, J Cho, I Kovanlikaya, J Anderson, ...
Magnetic resonance in medicine 86 (4), 2165-2178
 

The spatiotemporal evolution of MRI-derived oxygen extraction fraction and perfusion in ischemic stroke

D Wu, Y Zhou, J Cho, N Shen, S Li, Y Qin, G Zhang, S Yan, Y Xie, ...
Frontiers in Neuroscience 15, 716031
 

QQ‐NET–using deep learning to solve quantitative susceptibility mapping and quantitative blood oxygen level dependent magnitude (QSM+ qBOLD or QQ) based oxygen extraction …

J Cho, J Zhang, P Spincemaille, H Zhang, S Hubertus, Y Wen, R Jafari, ...
Magnetic resonance in medicine 87 (3), 1583-1594
 

Cerebral oxygen extraction fraction: comparison of dual‐gas challenge calibrated BOLD with CBF and challenge‐free gradient echo QSM+ qBOLD

J Cho, Y Ma, P Spincemaille, GB Pike, Y Wang
Magnetic resonance in medicine 85 (2), 953-961
 

Quantification of brain oxygen extraction fraction using QSM and a hyperoxic challenge

Y Ma, EL Mazerolle, J Cho, H Sun, Y Wang, GB Pike
Magnetic resonance in medicine 84 (6), 3271-3285
 

Robust MR assessment of cerebral blood volume and mean vessel size using SPION-enhanced ultrashort echo acquisition

SH Han, JH Cho, HS Jung, JY Suh, JK Kim, YR Kim, G Cho, H Cho
NeuroImage 112, 382-389
 

Comparison of gradient echo and gradient echo sampling of spin echo sequence for the quantification of the oxygen extraction fraction from a combined quantitative …

S Hubertus, S Thomas, J Cho, S Zhang, Y Wang, LR Schad
Magnetic resonance in medicine 82 (4), 1491-1503
 

Brain oxygen extraction and neural tissue susceptibility are associated with cognitive impairment in older individuals

GC Chiang, J Cho, J Dyke, H Zhang, Q Zhang, M Tokov, T Nguyen, ...
Journal of Neuroimaging 32 (4), 697-709
 

Application of cluster analysis of time evolution for magnetic resonance imaging-derived oxygen extraction fraction mapping: a promising strategy for the genetic profile …

N Shen, S Zhang, J Cho, S Li, J Zhang, Y Xie, Y Wang, W Zhu
Frontiers in Neuroscience 15, 736891
 

Spatiotemporal patterns of brain iron-oxygen metabolism in patients with Parkinson’s disease

S Yan, J Lu, Y Li, J Cho, S Zhang, W Zhu, Y Wang
European Radiology 34 (5), 3074-3083
 

UTE–ΔR2–ΔR2* combined MR whole‐brain angiogram using dual‐contrast superparamagnetic iron oxide nanoparticles

HS Jung, SH Jin, JH Cho, SH Han, DK Lee, H Cho
NMR in Biomedicine 29 (6), 690-701
 

Oxygen extraction fraction (OEF) assesses cerebral oxygen metabolism of deep gray matter in patients with pre-eclampsia

L Yang, J Cho, T Chen, KM Gillen, J Li, Q Zhang, L Guo, Y Wang
European Radiology 32 (9), 6058-6069
 

Cerebral oxygen extraction fraction declines with ventricular enlargement in patients with normal pressure hydrocephalus

H Zhuang, J Cho, GCY Chiang, I Kovanlikaya, LA Heier, JP Dyke, Y Wang
Clinical imaging 97, 22-27
 

Response of the primary auditory and non-auditory cortices to acoustic stimulation: a manganese-enhanced MRI study

H Kim, J Cho, YR Kim, Y Song, SI Chun, JY Suh, JK Kim, YH Ryu, ...
PloS one 9 (3), e90427
 

The central vein sign in multiple sclerosis lesions: Susceptibility relaxation optimization from a routine MRI multiecho gradient echo sequence

J Li, W Huang, X Luo, Y Wen, J Cho, I Kovanlikaya, SA Gauthier, ...
Journal of Neuroimaging 32 (1), 48-56
 

Neuroimaging of brain structure-function coupling mechanism in neuropsychiatric disorders

M Feng, H Wen, J Li, H Lv, J Cho, L Guo
Frontiers in Neuroscience 17, 1270645
 

Subsecond accurate myelin water fraction reconstruction from FAST‐T2 data with 3D UNET

J Kim, TD Nguyen, J Zhang, SA Gauthier, M Marcille, H Zhang, J Cho, ...
Magnetic Resonance in Medicine 87 (6), 2979-2988
 

Improved signal modeling in Quantitative Susceptibility Mapping using multi-echo complex Total Field Inversion (mcTFI)

Y Wen, T Nguyen, J Cho, P Spincemaille, Y Wang
Proc. Intl. Soc. Mag. Reson. Med 28, 3200
 

Coherence enhancement in quantitative susceptibility mapping by means of anisotropic weighting in morphology enabled dipole inversion

Y Kee, J Cho, K Deh, Z Liu, P Spincemaille, Y Wang
Magnetic Resonance in Medicine 79 (2), 1172-1180
 

Multi-Echo complex quantitative susceptibility mapping and quantitative blood oxygen Level-Dependent magnitude (mcQSM+ qBOLD or mcQQ) for oxygen extraction fraction (OEF) mapping

J Cho, J Zhang, P Spincemaille, H Zhang, TD Nguyen, S Zhang, A Gupta, ...
Bioengineering 11 (2), 131
 

Evaluating physiological MRI parameters in patients with brain metastases undergoing stereotactic radiosurgery—a preliminary analysis and case report

EE van Grinsven, J de Leeuw, JCW Siero, JJC Verhoeff, ...
Cancers 15 (17), 4298
 

Assessing cerebral oxygen metabolism changes in patients with preeclampsia using voxel-based morphometry of oxygen extraction fraction maps in magnetic resonance imaging

Q Zhang, C Sui, J Cho, L Yang, T Chen, B Guo, KMC Gillen, J Li, L Guo, ...
Korean Journal of Radiology 24 (4), 324
 

Optimal quantitative mapping of Cerabral Metabolic Rate of Oxygen (CMRO2) by combining quantitative susceptibility mapping (QSM)-based method and quantitative BOLD (qBOLD)

J Cho, Y Kee, P Spincemaille, T Nguyen, J Zhang, Y Wang
Proceedings of the 25th Annual Meeting of ISMRM; Hawaii, USA, Abstract 1110
 

Sensitivity assessment of QSM+ qBOLD (or QQ) in detecting elevated oxygen extraction fraction (OEF) in physiological change

P Elanghovan, T Nguyen, P Spincemaille, A Gupta, Y Wang, J Cho
Journal of Cerebral Blood Flow & Metabolism 45 (4), 735-745
 

The changes of oxygen extraction fraction in different types of lesions in relapsing–remitting multiple sclerosis: A cross-sectional and longitudinal study

Y Xie, S Zhang, D Wu, Y Yao, J Cho, J Lu, H Zhu, Y Wang, Y Zhang, ...
Neurological Sciences 45 (8), 3939-3949
 

Quantitative susceptibility mapping and R1 measurement: Determination of the myelin volume fraction in the aging ex vivo rat corpus callosum

H Cho, H Lee, Y Gong, YR Kim, J Cho, HJ Cho
NMR in Biomedicine 35 (3), e4645
 

Dipole modeling of multispectral signal for detecting metallic biopsy markers during MRI‐guided breast biopsy: a pilot study

S Eskreis‐Winkler, K Simon, M Reichman, P Spincemaille, T Nguyen, ...
Magnetic resonance in medicine 83 (4), 1380-1389
 

In MRI-based oxygen extraction fraction and cerebral metabolic rate of oxygen mapping in high-grade glioma using a combined quantitative susceptibility mapping and quantitative …

S Hubertus, S Thomas, J Cho, S Zhang, I Kovanlikaya, Y Wang, LR Schad
Proceedings of the International Society for Magnetic Resonance in Medicine …
 

Spincemaille Pascal, Wang Yi

Z Dong, C Junghun, Z Jingwei
Susceptibility under-estimation in a high-susceptibility phantom: Dependence …
 

Sensitivity of quantitative susceptibility mapping for clinical research in deep gray matter

F Salman, A Ramesh, T Jochmann, M Prayer, A Adegbemigun, ...
Human brain mapping 46 (6), e70187
 

Trajectories and sex differences of brain structure, oxygenation and perfusion functions in normal aging

D Wu, Y Li, S Zhang, Q Chen, J Fang, J Cho, Y Wang, S Yan, W Zhu, J Lin, ...
NeuroImage 302, 120903
 

System and method of accurate quantitative mapping of biophysical parameters from mri data

Y Wang, Y Wen, R Jafari, T Nguyen, P Spincemaille, J Cho, Q Zhang
US Patent App. 18/042,163
 

System and method of perceptive quantitative mapping of physical properties

Y Wang, Z Liu, J Zhang, Q Zhang, J Cho, P Spincemaille
US Patent 11,782,112
 

Quantitative susceptibility mapping of magnetic quadrupole moments

J Cho, D Zhou, Y Kee, P Spincemaille, Y Wang
Concepts in Magnetic Resonance Part A 2019 (1), 7174937
 

Feasibility of multispectral spin echo breast quantitative susceptibility mapping: an alternative to post-biopsy mammogram after MR-guided breast biopsy

S Eskreis-Winkler, K Simon, Y Kee, J Cho, T Nguyen, P Spincemaille, ...
 

Evaluation of MRI-based brain oxygen extraction fraction mapping in patients with systemic lupus erythematosus

S Zhang, J Ma, S Wu, Z Hu, S Yan, J Cho, Y Wang, L Dong, S Zhang, ...
Lupus Science & Medicine 12 (1)
 

Oxygen extraction fraction in small vessel disease: relationship to disease burden and progression

R Zhang, M Lin, J Cho, X Yu, Y Jiaerken, S Wang, H Hong, X Guan, ...
Brain 148 (6), 1950-1962
 

Potential Separation of Multiple System Atrophy and Parkinson’s Disease by Susceptibility-derived Components

S Yan, J Lu, B Duan, S Zhang, D Liu, Y Qin, AV Dimov, J Cho, Y Li, W Zhu, ...
NeuroImage, 121241
 

Magnetic resonance imaging physics and image acquisition

J Cho, A Dimov
Handbook of Imaging in Multiple Sclerosis, 137-158
 

Utilizing Oxygen Extraction Fraction to differentiate Multiple Sclerosis from Non-Multiple Sclerosis Fluid-Attenuated Inversion Recovery White Matter Lesions

G Vallejos, MH Khalil, S Keyes, T Shahraki, P Mashouf, J Cho, ...
MULTIPLE SCLEROSIS JOURNAL 30 (3), 933-934
 

System and method of perceptive quantitative mapping of physical properties

Y Wang, Z Liu, J Zhang, Q Zhang, J Cho, P Spincemaille
US Patent 12,072,403
 

Simulating Brain Gradient-Echo Magnetic Resonance Images through Microstructural Modeling

M Şişman, A Roberts, H Zhuang, R Hu, J Cho, S Zhang, P Spincemaille, ...
 

Quantitative evaluation of oxygen extraction fraction (OEF) in Alzheimer's disease: A correlation with tau and amyloid pathology and cognitive status

SA Hosseini, S Servaes, J Therriault, C Tissot, N Rahmouni, AC Macedo, ...
Journal of the Neurological Sciences 455
 

Neuroimaging of Brain Structure-Function Coupling Mechanism in Neuropsychiatric Disorders

J Cho, H Lv, L Guo, H Wen, J Li
Frontiers Media SA
 

Biophysics Model Improvement in Magnetic Resonance Imaging: Cerebral Metabolic Rate of Oxygen

J Cho
Cornell University
 

Coherence Enhancement in QSM via Anisotropic Weighting in Morphology-Enabled Dipole Inversion

Y Kee, P Spincemaille, J Cho, Y Wang
Proc. Intl. Soc. Mag. Reson. Med 25, 3674
 

The activity of the primary auditory cortex and auditory pathway under acoustic stimulation: a MEMRI Study

H Kim, J Cho, YR Kim, Y Song, SI Chun, JY Suh, JK Kim, YH Ryu, ...
Integrative Medicine Research 4 (1), 59
 

Assessing Abnormal Oxygen Extraction Fraction and Neural Tissue Susceptibility in Parkinson's Disease

A Misra, AM Oros-Peusquens, K Reetz, I Dogan, JB Schulz, C Ma, ...
Available at SSRN 5184105
 

Brain Oxygen Extraction Fraction in Patients with Normal Pressure Hydrocephalus

H Zhuang, J Cho, GCY Chiang, I Kovanlikaya, LA Heier, Y Wang
 

Regional oxygen extract fraction mapping (rOEF) of multiple sclerosis brains

J Cho, TD Nguyen, W Huang, S Zhang, X Luo, SA Gauthier, ...
 

Increase in Cerebral Oxygen Extraction Fraction in Early Parkinson’s Patients

HE Candan, D Lee, J Cho, H Lee, HJ Cho
 

MS-Voter: Learning Where to Vote for Confluent Multiple Sclerosis Lesion Separation

H Zhang, J Zhang, J Cho, SA Gauthier, P Spincemaille, TD Nguyen, ...
 

Combined cluster analysis of time evolution and tissue type with total variation denoising (CCTV) for QQ-based oxygen extract fraction mapping

J Cho, P Spincemaille, TD Nguyen, A Gupta, Y Wang
 

Quantitative Susceptibility Mapping from Deep-Learning Based Reconstruction of Undersampled Gradient-Recalled Echo Data

R Jafari, P Spincemaille, TD Nguyen, J Cho, MR Prince, Y Wang
 

Pronounced gender and lifestyle effects in the oxygen extraction fraction (OEF) of the ageing brain

AM Oros-Peusquens, L Hau, J Cho, N Bittner, S Caspers, Y Wang, ...
 

Multi-echo Complex QSM+ qBOLD (mcQQ) for Oxygen Extraction Fraction (OEF) mapping

J Cho, J Zhang, P Spincemaille, H Zhang, TD Nguyen, A Gupta, Y Wang
 

Assessment of age-related changes of oxygen extraction fraction in of normal adults using QSM and quantitative BOLD

J Wang, J Cho, C Zhang, Y Wang, B Yu
 

An improved data acquisition for robust oxygen extraction fraction (OEF) mapping using an integrative model of QSM and qBOLD (QSM+ qBOLD= QQ)

J Cho, P Spincemaille, TD Nguyen, Y Wang
 

Cerebral oxygen extraction fraction mapping: comparison of dual-gas challenge calibrated BOLD and challenge-free gradient echo QSM+ qBOLD

J Cho, Y Ma, P Spincemaille, B Pike, Y Wang
 

Cerebral Metabolic Rate of Oxygen (CMRO2) mapping by a joint model of quantitative susceptibility mapping (QSM)-based method and quantitative BOLD (qBOLD)

J Cho, Y Kee, P Spincemaille, T Nguyen, J Zhang, A Gupta, S Zhang, ...
 

Increased oxygen extraction fraction following acute multiple sclerosis (MS) lesion formation is associated with increased myelin repair.

J Cho, TD Nguyen, L Zexter, EM Sweeney, P Spincemaille, A Gupta, ...
 

Cerebral oxygen extraction fraction (OEF) mapping in cognitively impaired and intact elderly

J Cho, GC Chiang, J Dyke, H Zhang, Q Zhang, M Tokov, TD Nguyen, ...
 

Whole-brain OEF quantification: a comparison study between QSM and dual-gas calibrated BOLD

Y Ma, H Sun, J Cho, EL Mazerolle, Y Wang, GB Pike
 

Metabolic and vascular aspects of the ageing brain correlated with age, gender, lifestyle and intelligence

AM Oros-Peusquens, J Cho, L Hau, F Boers, N Bittner, S Caspers, ...
 

Effects of radiotherapy on tissue in patients with brain metastases in terms of OEF and CMRO2

J de Leeuw, J Cho, E van Grinsven, J Siero, M Philippens, A Bhogal
 

Using an Artificial Neural Network for Fast Mapping of the Oxygen Extraction Fraction with Combined QSM and qBOLD

S Hubertus, S Thomas, J Cho, S Zhang, Y Wang, LR Schad
 

A deep neural network for Oxygen Extraction Fraction (OEF) mapping based on No Training

A Ally, J Cho
 

Eight fold acceleration for isotropic T2w and T2FLAIR imaging using Multi-Contrast Second-Order Directional Total Generalized Variation (dTGV).

Y Kee, J Cho, T Nguyen, P Spincemaille, Y Wang
 

Data-driven regularized inversion (DRI) for improved QSM+ qBOLD based CMRO2 Mapping: a feasibility study in healthy subjects and ischemic stroke patients

J Cho, S Zhang, Y Kee, P Spincemaille, T Nguyen, S Hubertus, A Gupta, ...
 

Assessing cerebral oxygen metabolism changes in preeclampsia using voxel-based morphometry of oxygen extraction fraction (OEF) maps in MRI

C Sui, Q Zhang, J Cho, L Yang, T Chen, B Guo, KM Gillen, J Li, L Guo, ...
 

Quantitative susceptibility mapping of brain iron deposition in patients with cerebral small-vessel disease with cerebral microbleeds

L Guo, L Zhou, TD Nguyen, W Huang, J Cho, Y Wang
 

Initial experience using combined quantitative susceptibility mapping and quantitative bold oxygen level dependent imaging (QSM+ qBOLD) oxygen extraction fraction for …

S Zhang, J Cho, TD Nguyen, P Spincemaille, W Zhu, Y Wang
 
2024 May

UNY Buffalo, BME faculty award: “Rookie of the Year” Award

2022

ISMRM “Summa cum laude” merit award

2021 July

K99/R00 Career Development Award (NIH NINDS, 2021-2026):
Development and validation of MRI mapping of brain oxygen metabolism for clinical use

2021

ISMRM “Summa cum laude” merit award
Best Abstract Award - 1st place in ISMRM PET/MRI Study Group Meeting.
Best Abstract Award - 3rd place in ISMRM Electro-Magnetic Study Group Meeting

2020

Editor’s Pick for MRM publication
ISMRM “Magna cum laude” merit award

2018

ISMRM “Summa cum laude” merit award

2016-2018

Educational Stipend from the ISMRM

2008

University honors in the University of Michigan at Ann Arbor

2004-2006

Designated as Excellent Student in the Tokyo University of Agriculture and Technology

2004-2006

Korea-Japan Joint Government Scholarship